A large majority of the body’s immune system is located within the intestines.  When goodguts probiotic is consumed daily, it creates a healthier intestinal environment, supporting Immune function.  

Studies have shown that when the body is challenged (by colds and the flu for example) goodguts probiotic helps up regulate the protective cytokines which help fight the challenge.  When the body is challenged by over active cytokines (inflammation related to arthritis, for example) it helps down regulate these cytokines.

A Controlled Clinical Trial to Evaluate The Effects of Bacillus Coagulans On Immunological Markers. Methods and Findings in Experimental and Clinical Pharmacology 2010, 32(23): 129-132.  M. Kimmel, D. Keller, S. Farmer, D.E. Warrino.

A controlled trial that showed that Bacillus coagulans supports immune health by increasing immune response to multiple viral challenges and that a regimen of 500 million cfu of Bacillus coagulans per day may be a safe and effective option for enhancing the immunological response to common viral respiratory tract infections.

Bacillus Coagulans Modulates Faecalibacterium prausnitzii in Older Men and Women. The Journal of Nutrition May 2015. Edna P Nyangale, Sean Farmer, Howard A. Cash, David Keller, David Chernoff, and Glenn R Gibson.

Advancing age is linked to a decrease in beneficial bacteria and reduced aspects of innate immune function.  Daily consumption of the patented Bacillus coagulans by adults aged 65-80 can increase beneficial groups of bacteria in the human gut and potentially increase production of anti-inflammatory cytokines.  This study shows the potential benefits of a probiotic to improve dysbiosis via modulation of the microbiota in older persons.

Bacillus Coagulans Cell Wall and Metabolites: Anti-inflammatory and Immune Modulating Effects In Vitro. BMC Immunology 2010, 11:1.  Gitte S Jensen, Kathleen F Benson, Steve G Carter, John R Endres.

This study was performed to evaluate anti-inflammatory and  immune modulating properties of the patented bacillus coagulans..  The data suggests that consumption of Bacillus coagulans may introduce both cell wall components and metabolites that modulate inflammatory processes in the gut.  Both the cell wall and the supernatant possess strong immune modulating properties in vitro.  The anti-inflammatory effects are of interest to possible treatment of inflammatory bowel diseases as well as in support of a healthy immune system.

Probiotic metabolites from Bacillus Coagulans supports maturation of antigen-presenting cells in vitro. World Journal of Gastroenterology, 2012, 18(16): 1875-1883. Kathleen F Benson, Kimberlee A Redman, Steve G Carter, David Keller, Sean Farmer, John R Endres and Gitte S Jensen.

This research showed that a primary mechanism of action of the patented bacillus coagulans metabolites involves support of more mature phenotypes of antigen presenting cells, important for immunological decision-making.

A patented strain of Bacillus Coagulans Increased Immune Response to Viral Challenge. Postgraduate Medicine, 2009; 121(23): 114-118. Mira Baron.

Viral respiratory tract infection is the most common illness among humans.  Probiotics have been known to enhance the immune system and may represent therapeutic advancement for treating viral respiratory tract infections.  This study showed that Bacillus coagulans may be a safe and effective therapeutic option for enhancing T-cell response to certain viral respiratory tract infections.